69th SIF National Congress

Italian Physiological Society

Florence, Italy • 19-21 September 2018

Florence, Italy
19-21 September 2018

Florence, Italy
19-21 September 2018


  • Wednesday, 19 September

    Location: Aula Magna Hall of the University main building




    Pre-Symposium • The limits of human performance

    Chair: Guido Ferretti (Brescia, Italy)

    Andrea ZIGNOLI (Trento & Verona, Italy)
    Cycling: covering 60 km in 1 hour

    Jostein HALLÉN (Oslo, Norway)
    Skiing: performing the 50 km race in 100 min

    Guido FERRETTI (Brescia, Italy)
    Running a marathon in two hours

    Pietro Enrico di PRAMPERO (Udine, Italy)
    Sprint running: running the 100 m dash in 9.5 s

    General discussion


    Council of physiology professors


    Opening Ceremony


    Opening Lecture

    Marco NARICI (Padua, Italy)
    Muscle plasticity in use, disuse and ageing


    Welcome cocktail     [Courtyard of the University main building]


    Concert     [Sala Vanni – Basilica del Carmine]

  • Thursday, 20 September

    Location: Convitto della Calza


    Parallel Sessions

    Symposium • Glial plasticity     [Sala Pontevecchio]

    Chair: Cristina Limatola (Rome, Italy)

    Richard M. RANSOHOFF (Boston, MA, USA)
    Neuroinflammation: are OPCs the forgotten inflammatory glia?

    Cristina LIMATOLA (Rome, Italy)
    Microglial plasticity and brain functions

    Alexej VERKHRATSKY (Manchester, UK)
    Pathological plasticity of astroglia: from reactivity to astrodegeneration

    Fiorenzo CONTI (Ancona, Italy)
    Astrocyte-neuron communication as a mechanism to regulate network excitability and synaptic transmission

    Symposium • The orexin/hypocretin system: a key for a healthy life     [Sala Pitti]

    Chair: Chiara Berteotti (Bologna, Italy)

    Chiara BERTEOTTI (Bologna, Italy)
    Role of orexin signalling in physiological regulation: a lesson from narcoleptic mice

    Christian FRANCESCHINI (Parma, Italy)
    The psychological and psychosocial profile of Narcolepsy type 1: young and adult patients

    Marta PACE (Genoa, Italy)
    Study of melanin concentrating hormone and orexin/hypocretin neurons in the Prader-Willi syndrome

    Claudio LIGUORI (Rome, Italy)
    Orexin and Alzheimer's disease

    Symposium • New frontiers in cardiovascular physiology and protection. SIRC patronage
    [Sala Bargello]

    Chair: Teresa Pasqua (Cosenza, Italy)

    Carmine ROCCA (Arcavacata di Rende, CS, Italy)
    The emerging cardiac function of Selenoprotein T-derived peptide SelT43-52: from physiological to pathophysiological implications

    Saveria FEMMINÒ (Turin, Italy)
    Roles of extracellular vesicles in cardiovascular protection: bearers of good news

    Josè Manuel PIONER (Florence, Italy)
    Novel approaches for mechanistic studies on genetic cardiomyopathies using hiPSC-cardiomyocytes

    Andrea GERBINO (Bari, Italy)
    Cardiomyopathy caused by lamin A/C gene mutations: why is the functional characterization at cellular level so crucial?

    Francesco MOCCIA (Pavia, Italy)
    Intracellular Ca2+ signaling in endothelial progenitor cells: a useful tool to promote cardiac revascularization


    Coffee break     [Courtyard]


    Parallel Sessions

    Workshop • Cell physiology I: physiology of ion channels     [Sala Pontevecchio]

    Chairs: Corrado Poggesi (Florence, Italy), Maria Marino (Rome, Italy)

    Patrizia BENZONI (Milan, Italy)
    Assessing the arrhythmogenic risk associated with pathological mutations in the Caveolin-3 gene using both heterologous systems and patients’ iPSC- cardiomyocytes

    Monica CARMOSINO (Potenza, Italy)
    A C-terminus KCNH2 truncated mutant responsible for a Long QT type 2 Syndrome in an Italian family: from the functional characterization of the mutant to the mutant-specific therapy

    Tullio GENOVA (Turin, Italy)
    TRPM8 inhibits endothelial cell andhesion and migration via a nonchannel function by trapping the small GTPase Rap1

    Rita CANELLA (Ferrara, Italy)
    Potassium channels in alveolar epithelium cells: the particular case of the channel TREK-1

    Mariangela CENTRONE (Bari, Italy)
    Gi protein modulation of the potassium channel TASK2 mediates vesicle osmotic swelling and is required for non-secretory vesicle fusion

    Laura SIMONE (San Giovanni Rotondo, FG, Italy)
    AQP4 aggregation state is determinant for glioma cell fate


    Symposium • Physiology of smell     [Sala Pitti]

    Chair: Angela Corcelli (Bari, Italy)

    Thomas HUMMEL (Dresden, Germany)
    Olfaction in humans with reference to pathologies affecting the sense of smell

    Lucia LEONE (Rome, Italy)
    Role of adult subventricular zone neurogenesis in olfactory memory and their modulation by electromagnetic fields

    Michele DIBATTISTA (Bari, Italy)
    The long tale of calcium activated chloride channels in olfactory transduction

    Mattias ALENIUS (Umeå, Sweden)
    Hedgehog regulation of the odorant response

    Symposium • The good, the bad, and the ugly of reactive oxygen species: new insights from exercise, aging, and disease     [Sala Bargello]

    Chair: Massimo Venturelli (Verona, Italy)

    Russell S. RICHARDSON (Salt Lake City, UT, USA)
    ROS and the vasculature: implications for antioxidant and exercise treatment

    Federico SCHENA (Verona, Italy)
    The source of ROS during aging: the mild mitochondrial uncoupling phenomena

    Carlo REGGIANI (Padua, Italy)
    Mutual interplay between calcium and ROS in skeletal muscle fibers

    Massimo VENTURELLI (Verona, Italy)
    The impact of physical activity and oxidative stress on accelerated senescence


    Presidential Lecture     [Sala Pontevecchio]

    Pieter DE TOMBE (Harefield, UK)
    Frank-Starling law of the heart: molecular mechanisms


    Lunch and poster discussion      [Courtyard]


    Parallel Sessions

    Workshop • Neurobiology and neurophysiology I: integrative neuroscience     [Sala Pontevecchio]

    Chairs: Natale Belluardo (Palermo, Italy), Egidio D’Angelo (Pavia, Italy)

    Francesco BOLZONI (Milan, Italy)
    Disruption of intra-limb anticipatory postural adjustments in parkinsonian patients

    Chiara DELLA LIBERA (Verona, Italy)
    Habituation of oculomotor capture by irrelevant visual onsets hinges on a topographic map of the visual space

    Mara FABRI (Ancona, Italy)
    Cortical activation in mental rotation: observations in healthy subjects and split-brain patients

    Francesco PISANI (Bari, Italy)
    Recombinant expression of human Aquaporin-4 reveals new insights into the molecular physiology of orthogonal array of particles assembly and stability

    Stefano DI MARCO (L'Aquila, Italy)
    The dark side of the light: changes in retinal network following light damaging of photoreceptors

    Alessio MASI (Camerino, Italy)
    Electrophysiological alterations of the reward pathway in an animal model of autism

    Symposium • Role of autophagy in health and disease     [Sala Pitti]

    Chair: Anna Fassio (Genoa, Italy)

    Andrea BECCHETTI (Milan, Italy)
    HERG potassium channels, cell signaling and autophagy

    Kevin LÜTHY (Leuven, Belgium)
    Targeting synaptic TBC1D24 in epilepsy and DOORS syndrome

    Filippo ACCONCIA (Rome, Italy)
    Autophagy and hormone receptor levels: the case of the estrogen receptor α

    Anna FASSIO (Genoa, Italy)
    Autophagy and excitatory synapses: is there a role for v-ATPase?


    Organizer Symposium • Dual filament regulation of striated muscle: structure, function and malfunction     [Sala Bargello]

    Chair: Pieter de Tombe (Harefield, UK)

    Luca FUSI (London, UK)
    Thin- and Thick-filament based mechanisms for the dynamic regulation of contraction in skeletal and heart muscle

    Cecilia FERRANTINI (Florence, Italy)
    Thin filament proteins and HCM mutations

    Vincenzo LOMBARDI (Florence, Italy)
    Thick filament mechano-sensing in skeletal and cardiac muscles: a common mechanism able to adapt the energetic cost of the contraction to the task

    Leonardo NOGARA (Padua, Italy)
    Disrupting the super relaxed state of myosin to fight obesity and diabetes


    Museum visit

  • Friday, 21 September

    Location: Convitto della Calza


    Parallel Sessions

    Workshop • Cell physiology II: cell signaling     [Sala Pontevecchio]

    Chairs: Maria Marino (Rome, Italy), Maria Svelto (Bari, Italy)

    Giuseppe PROCINO (Bari, Italy)
    Pharmacological stimulation of Beta3-Adrenoreceptor in the kidney reveals a possible new role of sympathetic stimulation in regulating hydroelectrolytic homeostasis. Physiologic and possible therapeutic implications

    Massimo DAL MONTE (Pisa, Italy)
    Beta adrenoreceptor regulation of the HIF-1/VEGF axis in the diseased retina

    Fabio GIONFRA (Rome, Italy)
    Cross-talk between thyroid hormones and immune system

    Pawan FARIS (Pavia, Italy)
    Lysosomal Ca2+ signaling in metastatic colorectal carcinoma

    Elena GRASSELLI (Genoa, Italy)
    Modulation of inflammation and oxidative stress by a new thiazolidine compound (GQ-11) in a rat model of visceral ischemia

    Claudia BUSONERO (Rome, Italy)
    An in silico high throughput method to identify new pathways influencing the physiology of E2:ERα signaling


    Workshop • Neurobiology and neurophysiology II: cellular and molecular neuroscience     [Sala Pitti]

    Chairs: Egidio D’Angelo (Pavia, Italy), Natale Belluardo (Palermo, Italy)

    José MAYA-VETENCOURT (Genoa, Italy)
    Role of REST in adult ocular dominance plasticity

    Annalisa NOBILI (Rome, Italy)
    Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease

    Matteo PEDRAZZOLI (Verona, Italy)
    Glucocorticoid receptors are critical modulators of synaptic plasticity and microglia activity in 3xTg-AD mice hippocampus

    Maria Rosaria TROPEA (Catania, Italy)
    cAMP and cGMP specific phosphodiesterase inhibitors enhance memory in physiological conditions and Alzheimer’s disease

    Alessandro TOZZI (Perugia, Italy)
    Sexual neurosteroids can rapidly shape synaptic plasticity and attenuate the impairment of LTP in a rat model of cerebral amyloidosis

    Grazia NICCHIA (Bari, Italy)
    Characterization of OAP-null mice generated by CRISPR/Cas9

    Satellite Symposium • Advanced optical methods for morpho-functional investigations
    [Sala Bargello]

    Chair: Leonardo Sacconi (Florence, Italy)

    Anna Letizia Allegra MASCARO (Pisa, Italy)
    In vivo imaging of functional and structural plasticity after stroke

    Leonardo SACCONI (Florence, Italy)
    Optical dissection of cardiac electrophysiology: from single cell to whole heart

    Emilia ENTCHEVA (Washington DC, USA)
    All-optical cardiac electrophysiology for drug testing

    Marco MONGILLO (Padua, Italy)
    Optical interrogation of sympathetic nervous system in the heart

    Pasquale BIANCO (Florence, Italy)
    Force clamp in optical tweezers: a tool to study the structural dynamics of motors and filaments


    Coffee break      [Courtyard]


    Parallel Sessions

    Workshop • Metabolism, nutrition and system physiology     [Sala Pontevecchio]

    Chairs: Alberto Battezzati (Milan, Italy), Maria Carmela Cerra (Arcavacata Di Rende, CS, Italy)

    Assunta LOMBARDI (Naples, Italy)
    Absence of UCP3 impacts mitochondrial functionality and enzymatic antioxidant capacity in brown adipose tissue of mice acclimated at thermoneutrality

    Laura VERGANI (Genoa, Italy)
    Accumulation of lipid droplets in multiple steatogenic models of cultured hepatocytes affects cell stiffness in the single cell biomechanic model

    Francesco SOFI (Florence, Italy)
    Dietary intervention with vegetarian and Mediterranean diets for cardiovascular prevention: effects on hormones involved in the energy balance

    Amilcare BARCA (Lecce, Italy)
    Hyperglycaemic stress on fibroblasts: a study of the effects on murine NIH/3T3 cells exposed to exogenous carnosine1

    Eglantina IDRIZAJ (Florence, Italy)
    Evidence for adiponectin effects on the mechanical responses in strips from the mouse gastric fundus

    Marianna RANIERI (Bari, Italy)
    The Calcium-sensing Receptor (CaSR) expressed in vascular smooth muscle cell is involved in blood pressure regulation and protection from calcification

    Elena GROSSINI (Novara, Italy)
    Analysis of microvesicles pattern in preeclamptic women and of their effects on renal glomerular endothelial cells and podocytes, cultured alone or in co-stimulation

    Daniela NEGRINI (Varese, Italy)
    Lymphatic network distribution and function in the rat heart


    Workshop • Cell physiology III      [Sala Pitti]

    Chairs: Corrado Poggesi (Florence, Italy), Maria Marino (Rome, Italy)

    Nicoletta PLOTEGHER (Padua, Italy)
    GBA1 depletion compromises mitochondrial metabolism and sensitises neurons to calcium overload

    Lillà LIONETTI (Fisciano, SA, Italy)
    Mitochondrial function and dynamic behavior in response to different doses of environmental pollutant in HEPG2 cells

    Marco FIOCCHETTI (Rome, Italy)
    Neuro-protective effects of the 17β-estradiol/estrogen receptor/Neuroglobin pathway rely on mitochondrial dynamic modulation

    Francesco LODOLA (Milan, Italy)
    Conjugated polymers optically regulate the fate of Endothelial Progenitor Cells

    Laura CANESI (Genoa, Italy)
    Unraveling the physiological mechanisms involved in early development of marine bivalves

    Roberta SQUECCO (Florence, Italy)
    The environmental toxicant PCB153 promotes gap junctional impairment in liver stem-like cells through PP2A and Cer/C1P axis

    Laura BARBERIO (Arcavacata Di Rende, CS, Italy)
    Maternal Bisphenol A exposure compromise feto-placental unit growth associated to uterine artery endothelial dysfunction

    Valentina PALLOTTINI (Rome, Italy)
    Prenatal exposure to Bisphenol A induces alterations of cholesterol homeostasis in rat fetuses


    Workshop • Physiology of motor systems and exercise      [Sala Bargello]

    Chairs: Guido Ferretti (Brescia, Italy), Marco Linari (Florence, Italy)

    Feliciano PROTASI (Chieti, Italy)
    Transverse-tubule plasticity drives the assembly of Calcium Entry Units in muscle during exercise

    Simona BONCOMPAGNI (Chieti, Italy)
    Exercise prevents formation of Tubular Aggregates in ageing skeletal muscle fibers

    Massimo RECONDITI (Florence, Italy)
    Effect of temperature on thick filament-based regulation of mammalian skeletal muscle

    Chiara MOZZETTA (Rome, Italy)
    Inhibition of Histone H3 Lysine 9 methyltransferases promotes skeletal muscle repair and morphological recovery of dystrophic muscles

    Camilla PARMEGGIANI (Florence, Italy)
    Can liquid crystalline elastomers behave as effective artificial muscles?

    Paolo BRUSEGHINI (Brescia, Italy)
    Cardiovascular responses during rest-exercise and exercise-exercise transients

    Andrea D’AVELLA (Messina, Italy)
    The role of the cerebellum in the spatiotemporal organization of the muscle patterns for reaching

    Sara PARMIGIANI (Milan, Italy)
    Functional heterogeneity in the dorsal and medial premotor cortex during motor preparation revealed by transcranial magnetic stimulation mapping


    Lunch and poster discussion      [Courtyard]


    “Best Poster” pitch contest     [Sala Pontevecchio]


    Fabio Ruzzier Lecture     [Sala Pontevecchio]

    Lucia SIVILOTTI (London, UK)
    The activation of ligand-gated ion channels: a single-channel view


    Coffee break      [Courtyard]


    SIF general assembly     [Sala Pontevecchio]


    Social dinner      [Palazzo Borghese, via Ghibellina]

  • Posters

    When preparing your poster, please remember that its maximum size is 100 x 140 cm; width x height.

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    The scientific programme comprises two poster sessions: Session 1 on Thursday (13:00-15:30) and Session 2 on Friday (12:30-14:30).

    Poster presenters are required to be available for discussion during their assigned session.

    During the poster discussion, posters participating to the pitch contest selection (identified by a rosette collected at the front desk) will be screened by a committee of experts and 8 posters will be selected to access the pitch poster contest scheduled on Friday, 21 September, at 14:30. Ideal candidates must be under 40 without stable academic positions. Poster candidates are advised to have relevant slides on their poster ready, in the event of selection for the pitch contest. At the contest, presentations will be arranged in random order and presenters will have 5 min sharp (with slides) to convince the audience and the committee of their work.

    • Poster Session 1 • 20 September • 13:00-15:30

      Cell Physiology

      P1.1 Rosanna Avola (Catania)
      Hydroxytyrosol from olive fruits prevents blue light-induced premature skin photo aging 

      P1.2 Giorgia Bertoli (Milan)
      Effects of FGF23 on Sinoatrial Node activity

      P1.3 Giovanna Calabrese (Catania)
      Combination of 3D scaffold, mesenchymal stem cells and bioactive factors for osteo-chondral regeneration

      P1.4 Rosa Cardone (Bari)
      Extracellular matrix (ECM) composition influences pH regulation in PDAC parenchymal cell (CPC) and cancer stem cell (CSC) in organotypic 3D culture

      P1.5 Michela Castagna (Milan)
      Functional characterization of iron transporter Nramp2 from Dictyostelium discoideum

      P1.6 Ilaria Cataldo (Bari)
      Lack of Aquaporin-9 impairs the systemic inflammatory response of LPS-induced septic shock in mouse

      P1.7 Lidia De Riccardis (Lecce)
      Role of copper in the pathogenesis of Multiple Sclerosis

      P1.8 Ilaria Demori (Genoa)
      Anti-steatotic effects of an antimicrobial peptide isolated from amphibian skin

      P1.9 Elena Fabbri (Bologna)
      Evaluation of the estrogenic response to bisphenol A in trophoblast-derived HTR-8/SVneo cells: ERK1,2 pathway involvement and effect on cell migration

      P1.10 Bernard Fioretti (Perugia)
      Silver ions promote membrane blebbing protrusion in U251 glioblastoma cell by increasing intracellular calcium and hydrostatic pressure

      P1.11 Rosamaria Fiorini (Ancona)
      Oxidative stress and membrane fluidity in patients with cognitive impairment

      P1.12 Stefania Fulle (Chieti)
      Microgravity effects on human satellite cells

      P1.13 Maria Elena Giordano (Lecce)
      Antioxidant and pro-oxidant activity of Trolox and its effect on cell volume homeostasis on HeLa cells

      P1.14 Rosario Giuffrida (Catania)
      Melatonin-induced neural-like differentiation of human adipose mesenchymal stem cells

      P1.15 Adriana Graziano (Catania)
      Galactosylsphingosine levels exert a crucial role in oligodendrocytes homeostasis by affecting membrane signaling proteins

      P1.16 Elisa Greggio (Padua)
      Phosphorylation of 14-3-3 proteins by the kinase PAK6 as a novel regulatory mechanism to coordinate the activity of target proteins in the brain

      P1.17 Sara Landi (Milan)
      Investigating the functional alterations of iPS-derived cardiomyocytes from a 24-year-old patient with paroxysmal atrial fibrillation carrying the c. Ex6 A208G mutation in the PITX2 gene

      P1.18 Marzia Lecchi (Milan)
      Incubation with low doses of oxaliplatin modifies the electrophysiological properties of dorsal root ganglion neurons

      P1.19 Maria Giulia Lionetto (Lecce)
      A novel physiological role for carbonic anhydrase in animals: involvement in the lysosomal response to cadmium exposure in mussel digestive gland

      P1.20 Simona Lobasso (Bari)
      Cardiolipin fingerprinting in leukocytes of cardiopathic children

      P1.21 Filippo Locri (Pisa)
      The urokinase-type plasminogen activator receptor system plays an important role in regulating inflammation in retinal degeneration

      P1.22 Federico Formenti (London, United Kingdom)
      Human phenotype of a novel von Hippel-Lindau mutation

      Neurobiology and Neurophysiology

      P3.1 Antonella Amato (Palermo)
      A natural dietary supplement containing curcuma longa, silymarin, guggul, chlorogenic acid and inulin prevents neurodegeneration in experimental obesity

      P3.2 Marco Bisaglia (Padua)
      Alterations in redox homeostasis induce locomotion dysfunction in Drosophila melanogaster

      P3.3 Tommaso Bocci (Pisa)
      Amblyopia and the corpus callosum: a new evidence for an old debate 

      P3.4 Veronica Bonalume (Milan)
      Axonal GABAregulates somatosensory C-fiber excitability in peripheral nerve

      P3.5 Luigi Catacuzzeno (Perugia)
      Simulation of gating currents of the Shaker K channel using a Brownian model of the voltage sensor

      P3.6 Luisa Cigliano (Naples)
      Imbalance of redox homeostasis, autophagy activation, and modulation of synaptic markers in frontal cortex of young and adult rats are involved in the early response to a short term fructose feeding: an intriguing menage a trois

      P3.7 Laura Civiero (Padua)
      Dysfunctional calcium and glutamate signaling in Lrrk2-/- astroglia

      P3.8 Marinella Coco (Catania)
      Sleep deprivation and physiological responses. A case report

      P3.9 Marianna Crispino (Naples)
      Localization and synthesis of Cystatin B in the synaptic regions of rat brain cortex

      P3.10 Simona Damiano (Naples)
      5-hydroxytryptamine inhibits oligodendrocyte migration through NOX-dependent ROS generation

      P3.11 Maria Egle De Stefano (Rome)
      Hippocampal response to glucocorticoids in Duchenne Muscular Dystrophy: a route to post-traumatic stress disorders?

      P3.12 Mattia DiFrancesco (Genoa)
      Photoswitchable amphiphilic molecules for light-dependent modulation of neuronal activity

      P3.13 Valeria Fascianelli (Rome)
      Neuronal intrinsic timescales in the macaque dorsolateral prefrontal cortex and dorsal premotor cortex predict spatial response coding

      P3.14 Matteo Fecchio (Milan)
      Sleep-Like bistability, loss of causality and complexity in the cerebral cortex of unresponsive wakefulness syndrome patients

      P3.15 Leonardo Fogassi (Parma)
      Role of ventrolateral prefrontal cortex in action coding

      P3.16 Greta Forcaia (Monza)
      Modulation of intracellular Ca2+ concentration in brain microvascular endothelial cells actively induced by brain targeted liposomes

      P3.17 Giorgio Grasselli (Chicago, USA)
      Learning deficit associated with a selective and cell-type specific impairment of intrinsic plasticity in cerebellar Purkinje cells

      P3.18 Rosario Gulino (Catania)
      Smoothened agonists stimulate neural progenitor cells and functional restoration in a model of motoneuronal loss

      P3.19 Timna Hitrec (Bologna)
      Hypothalamic activity at torpor onset in mice

      P3.20 Ludovica Iovino (Florence)
      Tonic control of inhibitory neurons in the lamprey respiratory central pattern generator through 5-HT1A receptors

      P3.21 Paraskevi Krashia (Rome)
      The loss of midbrain DA neurons in Alzheimer's disease: deficits in the hippocampus-nucleus accumbens connectivity in the Tg2576 mouse model

      P3.22 Dominga Lapi (Naples)
      Mandibular extension in spontaneously hypertensive rats: a procedure to modulate the rhythmic arteriolar diameter oscillations in cortex

      P3.23 Carlotta Lega (Verona)
      Probing the neural mechanisms for distractor filtering and their history-contingent modulation by means of TMS

      P3.24 Teresa Lorenzi (Ancona)
      Identification and characterization of neurons in human indusium griseum

      P3.25 Andrea Sagrati (Ancona)
      Morfological and neurochemical analysis of the human corpus callosum

      P3.26 Teresa Mastantuono (Naples)
      Myricetin effects on rat pial microvascular injury and blood-brain barrier integrity

      P3.27 Andrea Mazzatenta (Chieti)
      The electrophysiological investigation of the human olfactory system

      P3.28 Marcello Melone (Ancona)
      Heterogeneity of astrocytic and neuronal GLT-1 at cortical excitatory synapses, as revealed by its co-localization with Na+/K+-ATPase α isoforms

      Physiology of Motor Systems and Exercise

      P4.1 Maria Angela Bagni (Florence)
      Muscle shortening manoeuvre is effective in human rehabilitation. A preliminary study on the mechanism of action: a murine model and an evaluation of H reflex in human healthy subjects

      P4.2 Barbara Colombini (Florence)
      Effect of fatigue and H2O2 on the contractile properties of intact muscle fibres and myofibrils isolated from the mouse diaphragm

      P4.3 Elisabetta Baldi (Florence)
      Can Muscle Shortening Manoeuvre (MSM) improve the stability and safety in patients with Parkinsons’ Disease?

      P4.4 Davide Cervia (Viterbo)
      Autophagy controls neonatal myogenesis by regulating the GH/IGF1 system through an Nfr2 and CHOP mediated mechanism

      P4.5 Giovanni Vinetti (Brescia)
      Energy cost and optimal speed of walking in high-heeled shoes

      P4.6 Marco Linari (Sesto Fiorentino, FI)
      In situ characterization of the working stroke of the slow and fast isoforms of muscle myosin

      P4.7 Irene Pertici (Sesto Fiorentino, FI)
      A combined study of the effect of Bovinic Acid on the mechanics and kinetics of the cardiac myosin

      P4.8 Gabriella Piazzesi (Sesto Fiorentino, FI)
      The OFF state of thick filament is maintained in the diastole of an intact trabecula also in the presence of inotropic interventions

      P4.9 Vittore Verratti (Chieti)
      Urinary physiology at altitude: effect of a moderate hypoxia on sympathovagal balance and urodynamic parameters

      P4.10 Marco Caremani (Sesto Fiorentino, FI)
      In situ measurement of the force and stiffness of cardiac myosin

    • Poster Session 2 • 21 September • 12:30-14:30

      Cell Physiology

      P1.23 Michele Maffia (Lecce)
      Novel candidates markers of oligodendrocytes differentiation

      P1.24 Simona Martinotti (Alessandria)
      Endothelial cells in tissue regeneration: the mastermind role of intracellular calcium in a PL-driven wound healing process

      P1.25 David Molla (Milan)
      The cardiac rate regulator Tong Mai Yang Xin: in-vivo effects in freely-moving mice

      P1.26 Valeria Pecci (Pisa)
      Targeting the urokinase-type plasminogen activator receptor system ameliorates renal dysfunction in a diabetes model

      P1.27 Noemi Anna Pesce (Pisa)
      Functional role of beta-3 adrenoceptors in a mouse model of oxygen-induced retinopathy

      P1.28 Federica Pessina (Siena)
      Protective effects of astrocytoma cells conditioned medium on differentiated neuroblastoma cells subjected to hypoxia and reperfusion

      P1.29 Giulia Petroni (Florence)
      Targeting hERG1 K+ channels with Macrolides Antibiotics induces a complex modulation of autophagy and apoptosis leading to Colorectal Cancer cell death

      P1.30 Nicoletta Piroddi (Florence)
      A novel homozigous  HCM mutation in cardiac Troponin T primarily alters cross-bridge kinetics and the energy cost of tension generation in human cardiac muscle

      P1.31 Alessia Remigante (Salzburg, Austria)
      Mapping of ICln protein O-GlcNac modification sites involved in the regulation of cellular volume

      P1.32 Maria Rossino (Pisa)
      Regulation of VEGF expression by VEGF in retinal disease

      P1.33 Giorgia Scarpellino (Turin)
      P2x7R-Dependent purinergic regulation of tumor vascularization

      P1.34 Beatrice Scellini (Florence)
      Myocardial overexpression of ANKRD1 affects developmental cardiac remodeling and leads to adult diastolic dysfunction

      P1.35 Sara Sergio (Lecce)
      β-catenin nuclear relocation links mechanical cues to cell growth and invasion in epithelial breast cancer cells

      P1.36 Maria Svelto (Bari)
      Water and solute transports across the peritoneal membrane: physiologic aspects and implications in peritoneal dialysis

      P1.37 Giovanna Valenti (Bari)
      CaSR activation in conditionally immortalized Proximal Tubular Epithelial Cells (ciPTEC) deficient for polycystin 1 or derived from ADPKD1 patients reverses the major intracellular dysregulations observed in ADPKD1

      P1.38 Giulia Vitale (Florence)
      The missense E258K-MyBP-C mutation increases the energy cost of tension generation in both ventricular and atrial tissue from HCM patients

      P1.39 Patrizia Lopalco (Bari)
      Human sperm lipid profiling in men with asthenospermia

      Metabolism, Nutrition and System Physiology

      P2.1 Maria Caterina Baccari (Florence)
      Glucagon-like peptide-2 (GLP-2) interferes with the vipergic neurotransmission in strips from mouse gastric fundus: functional and immunohistochemical evidence

      P2.2 Eleonora Bassino (Turin)
      Preventive role of natural compounds on glucose stressed human brain microvascular endothelial cells

      P2.3 Alberto Battezzati (Milan)
      First-level dietary intervention to decrease bisphenol a plasma in healthy subject: the 22nd school of physiology and biophysiscs pilot study

      P2.4 Simona Bertoli (Milan)
      Acute insulin secretory effects of a classic ketogenic meal in healthy subjects

      P2.5 Gianfranca Carta (Monserrato, CA)
      De novo lipogenesis as a physiological strategy to maintain adipose tissue homeostasis

      P2.6 Maria Cerra (Arcavacata di Rende, CS)
      SelT43-52, a Selenoprotein T-derived peptide, stimulates the cardiac performance of the goldfish Carassius auratus

      P2.7 Antonio Colantuoni (Naples)
      Effects of inorganic nitrate supplementation during weight loss on body composition and microvascular function in older obese subjects

      P2.8 Isy de Sousa (Fisciano, SA)
      Saturated and monounsaturated fatty acids time-dependent and dose-dependent effects on mitochondrial fusion and fission processes in HEPG2-cells

      P2.9 Monica Dinu (Florence)
      Khorasan wheat products’ consumption and non-alcoholic fatty liver disease (NAFLD): a randomized, double-blind trial

      P2.10 Giuditta Pagliai (Florence)
      Impact of Mediterranean vs Vegetarian diets on gut microbiota and short chain fatty acids: the CARDIVEG Study

      P2.11 Giovanna Zoccoli (Bologna)
      Glucose dynamics during daily torpor in laboratory mice

      P2.12 Maria Granieri (Arcavacata di Rende, CS)
      The novel function of Phoenixin14 as a cardioprotector in the obese rat

      P2.13 Sandra Imbrogno (Arcavacata di Rende, CS)
      AngII-dependent morpho-functional remodelling of the zebrafish heart

      P2.14 Daniele La Russa (Arcavacata di Rende, CS)
      Oxidative imbalance and kidney damage in cafeteria diet-induced rat model of metabolic syndrome: effect of bergamot polyphenolic fraction

      P2.15 Alessandro Leone (Milan)
      Development of a short questionnaire to assess the risk of Bisphenol A exposure: a pilot study

      P2.16 Giovanni Messina (Foggia)
      Effects of ketogenic diet on attentive skills in healthy volunteers

      P2.17 Maria Pina Mollica (Naples)
      Palmitoylethanolamide improves insulin sensitivity and lipid metabolism modulating mitochondrial function in hepatocyte carcinoma cells (HepG2) and mice fed a high-fat diet

      P2.18 Ilaria Di Gregorio (Fisciano, SA)
      White adipose tissue and brown adipose tissue adaptation in response to chronic exposure to high fat diet and environmental pollutant in rats

      P2.19 Pasquale Pagliaro (Orbassano, TO)
      Endothelial cell-derived extracellular vesicles display cardioprotective effects: is there a role for interleukin 3?

      P2.20 Teresa Pasqua (Arcavacata di Rende, CS)
      Chromogranin A-derived Catestatin: a new role in cardiac metabolism and physiology

      P2.21 Giuseppe Petito (Caserta)
      Browning of subcutaneous white adipose tissue (SAT) induced by 3,5-diiodothyronine (T2) in overweight rats

      P2.22 Rosa Serio (Palermo)
      Dopamine exerts opposite effects on the mechanical activity of circular and longitudinal muscle of human colon

      P2.23 Eleonora Solari (Varese)
      Lymphatic spontaneous contractility: TRP channels-mediated modulation by temperature and osmolarity

      P2.24 Giorgia Sollai (Monserrato, CA)
      The peripheral taste function in response to oleic acid depends on CD36 polymorphism (rs1761667) and PROP taster status

      P2.25 Simona Terzo (Palermo)
      Pistachio consumption reduces metabolic abnormalities in high-fat diet mouse model by modulating adipogenic gene expression

      P2.26 Francesca Vacca (Varese)
      A comparative electrophysiological analysis on the transport cycle of PepT1a and PepT1b, two di/tripeptide transporters from the Atlantic salmon Salmo salar

      Neurobiology and Neurophysiology

      P3.29 Maria Mola (Bari)
      Plasma Activated Liquid Medium (PALM) treatment to modulate astrocyte activation and migration

      P3.30 Claudio Molinari (Novara)
      Role of combined lipoic acid and vitamin D3 on astrocytes as a way to prevent brain ageing

      P3.31 Giuseppa Mudò (Palermo)
      Anti-inflammatory and antioxidant effects of muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus

      P3.32 Donatella Mutolo (Florence)
      Acetylcholine downregulates the cough reflex in the caudal nucleus tractus solitarii of the rabbit

      P3.33 Simon Nougaret (Rome)
      Learning the meanings of new stimuli increase the cross-correlated activity of prefrontal neurons

      P3.34 Pierpaolo Pani (Rome)
      Signs of cortical electrical activity after cardiac arrest

      P3.35 Carla Perego (Milan)
      The serine-threonine kinase LRRK2 controls Ca2+-channel targeting to the plasma membrane and its pathological mutants affect neurites extension and synaptic vesicles trafficking through modulation of Ca2+-current dynamics

      P3.36 Daniela Pietrobon (Padua)
      Increased activation of cortical pyramidal cell NMDA receptors as a consequence of reduced rate of glutamate clearance by astrocytes in a genetic mouse model of migraine

      P3.37 Daniela Puzzo (Catania)
      Role of endogenous tau in synaptic plasticity and memory impairment induced by amyloid-beta oligomers

      P3.38 Ilaria Rivolta (Monza)
      HCN1 novel mutations in familiar generalized epilepsy

      P3.39 Silvia Maria Marchese (Milan)
      Anodal tDCS on parietal operculum does not affect the programming of intra-limb anticipatory postural adjustments

      P3.40 Giulio Sancini (Monza)
      Oxcarbazepine free or loaded PLGA nanoparticles as effective intranasal delivery to control epileptic seizures

      P3.41 Simone Sarasso (Milan)
      Cortical perturbations reveal local sleep-like down states in cortical perilesional areas

      P3.42 Angelita Tottene (Padua)
      Short-term plasticity of thalamocortical synaptic transmission in a genetic mouse model of migraine: an excitation-inhibition imbalance revealed

      P3.43 Giovanna Traina (Perugia)
      Application of a high oral splint in the treatment of temporomandibular pain

      P3.44 Nunzio Vicario (Catania)
      MOR/DOR targeting mediates neuropathic pain amelioration in chronic constriction injured rats